Effects and safety of different anisodamine doses on EVLW at early stage of septic shock patients

• Main Authors: Ri-Xing Wang, Ming-Qiang Lin, Jia-Cong Lin
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Anisodamine Septic Shock EVLWI
• Online Access: http://www.hnykdxxb.com/PDF/201707/11.pdf

Objective: To investigate the effects and safety of different anisodamine doses on EVLW at early stage of septic shock patients. Method: A total of 63 patients with septic shock were enrolled in ICU, and they were randomly divided into control group (C group, 20 cases), normal anisodamine doses group (N group, 25 cases, anisodamine 20–40 mg/d), high anisodamine doses group (H group, 18 cases，anisodamine 80 mg/d). To observe the dynamic changes of temperature (T), heart rate (HR), oxygenation index (OI), cardiac index (CI), intrathoracic blood volume index (ITBVI), and extravascular lung water index (EVLWI). Results: 12 h after treatment, compared with C and N group, CI and ITBVI significantly increased in H group, EVLWI significantly decreased in H group. Meanwhile, T and HR significantly increased in H group, oxygenation index significantly decreased in H group. Some patients are unable to tolerate anisodamine treatment which leads to cessation of experiment. Compared with C group, EVLWI, CI, ITBVI, oxygenation index significantly improved in N group (P＜0.05), mortality rates significantly decreased (P＜0.05). Conclusions: Normal anisodamine doses would significantly decreased EVLWI and significantly improved outcomes, high anisodamine dose is not recommended on EVLWI in patients with septic shock.