Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness and an accumulation of solid stress in the tumor interior. So far, it is n...

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Bibliographic Details
Main Authors: Maria Kalli, Triantafyllos Stylianopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Oncology
Subjects:
extracellular matrix
fibroblasts
externally applied stress
growth-induced stress
in vitro models
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00055/full

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