Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats

• Main Authors: Saritha Marella, Dilip Rajasekhar Maddirela, Kameswara Rao Badri, Malaka Venkateshwarulu Jyothi Kumar, Apparao Chippada
• Format: Article
• Language: English
• Published: Cell Physiol Biochem Press GmbH & Co KG 2015-02-01
• Series: Cellular Physiology and Biochemistry
• Subjects: Diabetes mellitus; Streptozotocin; Mcy protein; Momordica cymbalaria; Antihyperlipidemic; Atherosclerosis
• Online Access: http://www.karger.com/Article/FullText/373954

Background: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic “Mcy protein” isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. Materials and Methods: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. Results: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (pConclusion: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.