Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages

Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages

Polarization of macrophages to proinflammatory M1 and to antiinflammatory alternatively activated M2 states has physiological implications in the development of experimental hypertension and other pathological conditions. 12/15-Lipoxygenase (12/15-LO) and its enzymatic products 12(S)- and 15(S)-hydr...

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Bibliographic Details
Main Authors: Tamas Kriska, Michael J. Thomas, John R. Falck, William B. Campbell
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Lipid Research
Subjects:
12(S)-HETE metabolism
angiotensin II
12/15-lipoxygenase
cytochrome P450
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339134

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http://www.sciencedirect.com/science/article/pii/S0022227520339134

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