IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa

IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa

Murid herpesvirus-4 (MuHV-4), a natural gammaherpesvirus of rodents, can infect the mouse through the nasal mucosa, where it targets sustentacular cells and olfactory neurons in the olfactory epithelium before it propagates to myeloid cells and then to B cells in lymphoid tissues. After establishmen...

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Bibliographic Details
Main Authors: Sophie Jacobs, Caroline Zeippen, Fanny Wavreil, Laurent Gillet, Thomas Michiels
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Viruses
Subjects:
gammaherpesvirus
murid herpesvirus 4
interferon-lambda
type III interferon
respiratory infection
vaginal mucosa
olfactory epithelium
Online Access:https://www.mdpi.com/1999-4915/11/8/757

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