Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist

<p>Abstract</p> <p>Pharmacodynamic assays are important in clinical trial design to investigate the relationship between drug concentration (pharmacokinetics) and drug "effect' or biological activity. Increasingly flow cytometry is being used to examine the pharmacodynami...

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Bibliographic Details
Main Authors: Lackey Alan, Wyant Timothy, Green Marie
Format: Article
Language:English
Published: BMC 2008-12-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/6/1/76

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