Hypothesis and Theory: A Pathophysiological Concept of Stroke-Induced Acute Phase Response and Increased Intestinal Permeability Leading to Secondary Brain Damage

Hypothesis and Theory: A Pathophysiological Concept of Stroke-Induced Acute Phase Response and Increased Intestinal Permeability Leading to Secondary Brain Damage

Gut integrity impairment leading to increased intestinal permeability (IP) is hypothesized to be a trigger of critically illness. Approximately 15–20% of human ischemic stroke (IS) victims require intensive care, including patients with impaired level of consciousness or a high risk for developing l...

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Bibliographic Details
Main Authors: Fabienne Ferrara, Vilia Zeisig, Sören Pietsch, Rita Rütten, Antje Y. Dreyer, Laura Pieper, Ann-Kathrin Schatzl, Damian D. McLeod, Henryk Barthel, Johannes Boltze, Wieland Schrödl, Björn Nitzsche
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
ischemic stroke
immune response
intestinal permeability
acute phase proteins
systemic inflammation
large animal stroke models
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00272/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00272/full

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