Hepatoprotective Effects of Against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

• Main Authors: Jie Li, Dan Song, Bintao Zhang, Jinwei Guo, Wenping Li, Xiaoying Zhang, Qin Zhao
• Format: Article
• Language: English
• Published: SAGE Publishing 2021-07-01
• Series: Dose-Response
• Online Access: https://doi.org/10.1177/15593258211029510

Purpose: To determine the hepatoprotective mechanisms of Heracleum candicans in rats with acute liver injury induced by carbon tetrachloride (CCl 4 ). Methods: Rats were intragastrically administered H candicans twice a day for 14 consecutive days and were intraperitoneally challenged with CCl 4 . Alanine aminotransferase and aspartate aminotransferase were measured to indicate liver injury. Malondialdehyde antioxidant enzyme activity and tumor necrosis factor-alpha and interleukin 6 secretion were measured as liver injury indicators. Histopathological tests were conducted to determine whether H candicans ameliorated liver injury. Results: CCl 4 -induced liver injury led to significant increases in liver injury biochemical indicators transaminase and malondialdehyde activities. H candicans pretreatments inhibited these increases. Pathological sections in pretreated samples exhibited reduced vacuole formation, neutrophil infiltration, and necrosis. Conclusion: H candicans increases the antioxidant capacity of the liver and maintains hepatocyte function in the face of CCl 4 -induced injury.