Parametry metabolizma i gemostazapri endogennom giperkortitsizme s narusheniemuglevodnogo obmena

• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2011-09-01
• Series: Ожирение и метаболизм
• Subjects: эндогенный гиперкортицизм; сахарный диабет; липиды; тромбоцитарно-коагуляционный гемостаз
• Online Access: https://endojournals.ru/index.php/omet/article/view/4833

The aim of the study was to determine peculiarities of protein and lipid metabolism as well as platelet-coagulation hemostasis depending on the pathogenesis of the endogenous hypercortisolism and assessment of the impact of chronic hyperglycemia on studied parameters. Materials and methods. The study included 19 patients with pituitary microadenomas with median age of 45,0 (41; 49) years and 9 patients with nodular adrenal gland hyperplasia aged 49,5 (42; 57) years, 14 of whom had diabetes mellitus. Results. Biochemical and coagulation parameters in patients with endogenous hyperpercortisolism regardless of ethiology Cushing`s syndrome differed from the control group in increased concentration of total cholesterol, high-density lipoproteins, low-density lipoproteins, alpha2-globulins and decreased gamma globulins, as well as in increased average volume of platelets and enhanced aggregation properties. Carbohydrate metabolism disorders were not characterized by significant differences in metabolic parameters and platelet hemostasis, but were accompanied by the reduction of APTT.