Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K<sub>2P</sub>) and voltage-gated (K<sub>v</sub>1.1 and K<sub>v</sub>1.2) potassium channels

Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K<sub>2P</sub>) and voltage-gated (K<sub>v</sub>1.1 and K<sub>v</sub>1.2) potassium channels

<p>Abstract</p> <p>Background</p> <p>Imiquimod (IQ) is known as an agonist of Toll-like receptor 7 (TLR7) and is widely used to treat various infectious skin diseases. However, it causes severe itching sensation as its side effect. The precise mechanism of how IQ causes...

Full description

Bibliographic Details
Main Authors:	Lee Jaekwang, Kim Taekeun, Hong Jinpyo, Woo Junsung, Min Hyunjung, Hwang Eunmi, Lee Sung, Lee C Justin
Format:	Article
Language:	English
Published:	SAGE Publishing 2012-01-01
Series:	Molecular Pain
Online Access:	http://www.molecularpain.com/content/8/1/2

Similar Items

K<sub>V</sub>1.5–K<sub>V</sub>β1.3 Recycling is PKC-Dependent
by: Alvaro Macias, et al.
Published: (2021-01-01)

K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
by: Magdalena Kowalska, et al.
Published: (2020-10-01)

Contribution of the Potassium Channels K<sub>V</sub>1.3 and K<sub>Ca</sub>3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries
by: Manuel Lasch, et al.
Published: (2020-04-01)

<i>N</i>-Glycosylation of TREK-1/hK<sub>2P</sub>2.1 Two-Pore-Domain Potassium (K<sub>2P</sub>) Channels
by: Felix Wiedmann, et al.
Published: (2019-10-01)

Current estimates of K<sub>1</sub>* and K<sub>2</sub>* appear inconsistent with measured CO<sub>2</sub> system parameters in cold oceanic regions
by: O. Sulpis, et al.
Published: (2020-07-01)

Hybrid Cathodes Composed of K<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> and Carbon Materials with Boosted Charge Transfer for K-Ion Batteries
by: Xianghua Zhang, et al.
Published: (2020-01-01)

Discussion and Comments on K<sub>OP</sub> and ∆K<sub>eff</sub>
by: Daniel Kujawski
Published: (2020-11-01)

The metabolism of vitamin K particularly vitamin K<sub>1</sub>
by: Taylor, Jack Dean
Published: (2010)

Growth Kinetics of the (110) Faces of Complex Potassium Cobalt–Nickel Sulphate K<sub>2</sub>Co<sub>x</sub>Ni<sub>1−x</sub>(SO<sub>4</sub>)<sub>2</sub>·6H<sub>2</sub>O Crystals
by: Dmitry A. Vorontsov, et al.
Published: (2021-06-01)

On the system of rational difference equations <it>x</it><sub><it>n</it>+1</sub> = <it>f</it>(<it>x</it><sub><it>n</it></sub>,<it>y</it><sub><it>n</it>-<it>k</it></sub>), <it>y</it><sub><it>n</it>+1</sub> = <it>f</it>(<it>y</it><sub><it>n</it></sub>, <it>x</it><sub><it>n</it>-<it>k</it></sub>)
by: Xi Hongjian, et al.
Published: (2006-01-01)

Tyrosine Phosphorylation of the K<sub>v</sub>2.1 Channel Contributes to Injury in Brain Ischemia
by: Min-Young Song, et al.
Published: (2020-12-01)

E<sub>m</sub>/E<sub>k</sub>/1的輸出過程
by: 李原旭

On the Consecutive <i>k</i><sub>1</sub> and <i>k</i><sub>2</sub>-out-of-<i>n</i> Reliability Systems
by: Ioannis S. Triantafyllou
Published: (2020-04-01)

Crystal-to-Crystal Transformation from K<sub>2</sub>[Co(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]·4H<sub>2</sub>O to K<sub>2</sub>[Co(μ-C<sub>2</sub>O<sub>4</sub>)(C<sub>2</sub>O<sub>4</sub>)]
by: Bin Zhang, et al.
Published: (2021-05-01)

Preparation and Dielectric Properties of K<sub>1/2</sub>Na<sub>1/2</sub>NbO<sub>3</sub> Ceramics Obtained from Mechanically Activated Powders
by: Izabela Szafraniak-Wiza, et al.
Published: (2020-01-01)

Determination of Vitamins K<sub>1, </sub>K<sub>2</sub> MK-4, MK-7, MK-9 and D<sub>3 </sub>in Pharmaceutical Products and Dietary Supplements by TLC-Densitometry.
by: Urszula Hubicka, et al.
Published: (2020-07-01)

Theoretical investigations of thermodynamic properties of partially deuterated K(H<sub>1-x</sub>D<sub>x</sub>)<sub>2</sub>PO<sub>4</sub> ferroelectrics
by: R.R.Levitskii, et al.
Published: (2007-01-01)

Crystal Chemical Relations in the Shchurovskyite Family: Synthesis and Crystal Structures of K<sub>2</sub>Cu[Cu<sub>3</sub>O]<sub>2</sub>(PO<sub>4</sub>)<sub>4</sub> and K<sub>2.35</sub>Cu<sub>0.825</sub>[Cu<sub>3</sub>O]<sub>2</sub>(PO<sub>4</sub>)<sub>4</sub>
by: Ilya V. Kornyakov, et al.
Published: (2021-07-01)

High-Pressure Phase Diagrams of Na<sub>2</sub>CO<sub>3</sub> and K<sub>2</sub>CO<sub>3</sub>
by: Pavel N. Gavryushkin, et al.
Published: (2019-09-01)

Pharmacological Approaches for the Modulation of the Potassium Channel K<sub>V</sub>4.x and KChIPs
by: Pilar Cercós, et al.
Published: (2021-01-01)

Simulation of CO<sub>2</sub> Absorption Using the System K<sub>2</sub>CO<sub>3</sub>- Piperazine
by: M. Arshad, et al.
Published: (2014-08-01)

Electronic and Thermoelectric Properties of V<sub>2</sub>O<sub>5</sub>, MgV<sub>2</sub>O<sub>5</sub>, and CaV<sub>2</sub>O<sub>5</sub>
by: Xiaofei Sheng, et al.
Published: (2020-05-01)

Limitation of K<sub>2</sub>CO<sub>3</sub> as a Chemical Agent for Upgrading Activated Carbon
by: Ji-Hyun Kim, et al.
Published: (2021-06-01)

The Effects of MnO<sub>2</sub> Addition on the Physical Properties of Pb(Ni<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub>-Pb(Zr,Ti)O<sub>3</sub>-Pb(Mg<sub>1/2</sub>W<sub>1/2</sub>)O<sub>3</sub>-BiFeO<sub>3</sub> Ceramics
by: Juhyun Yoo, et al.
Published: (2021-03-01)

Centipede KCNQ Inhibitor SsTx Also Targets K<sub>V</sub>1.3
by: Canwei Du, et al.
Published: (2019-02-01)

The baric changes of the refractive properties of K<sub>2</sub>SO<sub>4</sub> crystals
by: V.Yo.Stadnyk, et al.
Published: (2007-01-01)

A family of putative K<sub>ir</sub> potassium channels in prokaryotes
by: Guy H Robert, et al.
Published: (2001-12-01)

Oxidation of SO<sub>2</sub> by H<sub>2</sub>O<sub>2</sub> on ice surfaces at 228 K: a sink for SO<sub>2</sub> in ice clouds
by: S. M. Clegg, et al.
Published: (2001-01-01)

Interferometric Study of the Stability of K<sub>2</sub>Co<sub>x</sub>Ni<sub>(1−x)</sub>(SO<sub>4</sub>)<sub>2</sub>·6H<sub>2</sub>O (KCNSH) Mixed Crystal Faces Depending on the Composition and Flow Velocity of the Solution
by: Vadim V. Grebenev, et al.
Published: (2020-12-01)

Synthesis and Characterization of Ammonium Potassium Tellurium Polyoxomolybdate: (NH<sub>4</sub>)<sub>2</sub>K<sub>2</sub>TeMo<sub>6</sub>O<sub>22</sub>·2H<sub>2</sub>O with One-Dimensional Anionic Polymeric Chain [TeMo<sub>6</sub>O<sub>22</sub>]<sup>4−</sup>
by: Lei Geng, et al.
Published: (2021-04-01)

Insights into the Microstructure of Hydrothermal Synthesized Nanoscale K<sub>2</sub>O-Al<sub>2</sub>O<sub>3</sub>-SiO<sub>2</sub>-H<sub>2</sub>O Particles
by: Bao Liu, et al.
Published: (2019-12-01)

Recovery of K<sub>2</sub>SO<sub>4</sub> and Separation of SiO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub> from Brown Corundum Fly Ash
by: Yuandong Xiong, et al.
Published: (2020-11-01)

The effects of multiple features of alternatively spliced exons on the <it>K</it><sub><it>A</it></sub><it>/K</it><sub><it>S </it></sub>ratio test
by: Chen Feng-Chi, et al.
Published: (2006-05-01)

<i>D. russelii</i> Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of K<sub>v</sub> and K<sub>Ca</sub> Channels
by: Rahini Kakumanu, et al.
Published: (2019-04-01)

Gas sensor based on photonic crystal fibres in the 2v<sub>3</sub> and v<sub>2</sub>+ 2v<sub>3</sub>
by: Cubillas, Ana M., et al.
Published: (2009)

Microstructure and Flux Pinning of Reacted-and-Pressed, Polycrystalline Ba<sub>0.6</sub>K<sub>0.4</sub>Fe<sub>2</sub>As<sub>2</sub> Powders
by: Michael R. Koblischka, et al.
Published: (2019-07-01)

Increase of ATP-sensitive potassium (K<sub>ATP</sub>) channels in the heart of type-1 diabetic rats
by: Chen Zhih-Cherng, et al.
Published: (2012-01-01)

Triterpene Glycosides from the Far Eastern Sea Cucumber <i>Thyonidium (=Duasmodactyla) kurilensis </i>(Levin): The Structures, Cytotoxicities, and Biogenesis of Kurilosides A<sub>3</sub>, D<sub>1</sub>, G, H, I, I<sub>1</sub>, J, K, and K<sub>1</sub>
by: Alexandra S. Silchenko, et al.
Published: (2021-03-01)

Bisoprolol, Known to Be a Selective β<sub>1</sub>-Receptor Antagonist, Differentially but Directly Suppresses I<sub>K(M)</sub> and I<sub>K(erg)</sub> in Pituitary Cells and Hippocampal Neurons
by: Edmund Cheung So, et al.
Published: (2019-02-01)

The Poisoning of V<sub>2</sub>O<sub>5</sub>-WO<sub>3</sub>/TiO<sub>2</sub> and V<sub>2</sub>O<sub>5</sub>-Ce(SO<sub>4</sub>)<sub>2</sub>/TiO<sub>2</sub> SCR Catalysts by KCl and The Partial Regeneration by SO<sub>2</sub>
by: Hua Nie, et al.
Published: (2020-02-01)