Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient

Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common...

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Main Authors:	Takamistu Uchi, MD, Tsutomu Inaoka, MD, PhD, Noriko Kitamura, MD, PhD, Rumiko Ishikawa, MD, PhD, Tomoya Nakatsuka, MD, PhD, Shusuke Kasuya, MD, Wataru Tokuyama, MD, PhD, Nobuyuki Hiruta, MD, PhD, Hiroshi Takahashi, MD, PhD, Hitoshi Terada, MD, PhD
Format:	Article
Language:	English
Published:	Elsevier 2020-06-01
Series:	Radiology Case Reports
Subjects:	Diffuse astrocytoma Spinal cord Neurofibromatosis Follow-up MRI Biopsy
Online Access:	http://www.sciencedirect.com/science/article/pii/S1930043320300741

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spelling	doaj-5425d3854ff749cc8cec07d52d190c012020-11-25T02:19:33ZengElsevierRadiology Case Reports1930-04332020-06-01156784788Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patientTakamistu Uchi, MD0Tsutomu Inaoka, MD, PhD1Noriko Kitamura, MD, PhD2Rumiko Ishikawa, MD, PhD3Tomoya Nakatsuka, MD, PhD4Shusuke Kasuya, MD5Wataru Tokuyama, MD, PhD6Nobuyuki Hiruta, MD, PhD7Hiroshi Takahashi, MD, PhD8Hitoshi Terada, MD, PhD9Department of Radiology, Toho University Sakura Medical CenterDepartment of Radiology, Toho University Sakura Medical Center; Corresponding author.Department of Radiology, Toho University Sakura Medical CenterDepartment of Radiology, Toho University Sakura Medical CenterDepartment of Radiology, Toho University Sakura Medical CenterDepartment of Radiology, Toho University Sakura Medical CenterDivision of Surgical Pathology, Toho University Sakura Medical CenterDivision of Surgical Pathology, Toho University Sakura Medical CenterDepartment of Orthopedic Surgery, Toho University Sakura Medical CenterDepartment of Radiology, Toho University Sakura Medical CenterNeurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. So far, the occurrence of spinal cord malignancies is exceedingly rare. Herein, we report a rare case of a 69-year-old male with NF1 following tumor resection twice for cutaneous MPNSTs developing intramedullary diffuse astrocytoma in the conus medullaris, which initially presented with traumatic spinal cord injury associated with a compression fracture from fall. Contrast-enhanced magnetic resonance imaging and biopsy of the spinal cord were required to establish the final diagnosis.http://www.sciencedirect.com/science/article/pii/S1930043320300741Diffuse astrocytomaSpinal cordNeurofibromatosisFollow-up MRIBiopsy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Takamistu Uchi, MD Tsutomu Inaoka, MD, PhD Noriko Kitamura, MD, PhD Rumiko Ishikawa, MD, PhD Tomoya Nakatsuka, MD, PhD Shusuke Kasuya, MD Wataru Tokuyama, MD, PhD Nobuyuki Hiruta, MD, PhD Hiroshi Takahashi, MD, PhD Hitoshi Terada, MD, PhD
spellingShingle	Takamistu Uchi, MD Tsutomu Inaoka, MD, PhD Noriko Kitamura, MD, PhD Rumiko Ishikawa, MD, PhD Tomoya Nakatsuka, MD, PhD Shusuke Kasuya, MD Wataru Tokuyama, MD, PhD Nobuyuki Hiruta, MD, PhD Hiroshi Takahashi, MD, PhD Hitoshi Terada, MD, PhD Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient Radiology Case Reports Diffuse astrocytoma Spinal cord Neurofibromatosis Follow-up MRI Biopsy
author_facet	Takamistu Uchi, MD Tsutomu Inaoka, MD, PhD Noriko Kitamura, MD, PhD Rumiko Ishikawa, MD, PhD Tomoya Nakatsuka, MD, PhD Shusuke Kasuya, MD Wataru Tokuyama, MD, PhD Nobuyuki Hiruta, MD, PhD Hiroshi Takahashi, MD, PhD Hitoshi Terada, MD, PhD
author_sort	Takamistu Uchi, MD
title	Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient
title_short	Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient
title_full	Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient
title_fullStr	Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient
title_full_unstemmed	Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient
title_sort	unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly nf1 patient
publisher	Elsevier
series	Radiology Case Reports
issn	1930-0433
publishDate	2020-06-01
description	Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. So far, the occurrence of spinal cord malignancies is exceedingly rare. Herein, we report a rare case of a 69-year-old male with NF1 following tumor resection twice for cutaneous MPNSTs developing intramedullary diffuse astrocytoma in the conus medullaris, which initially presented with traumatic spinal cord injury associated with a compression fracture from fall. Contrast-enhanced magnetic resonance imaging and biopsy of the spinal cord were required to establish the final diagnosis.
topic	Diffuse astrocytoma Spinal cord Neurofibromatosis Follow-up MRI Biopsy
url	http://www.sciencedirect.com/science/article/pii/S1930043320300741
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Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient

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