Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-ter...
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doaj-5424205f41c74bc7a3acee186f9df9972020-11-25T01:41:51ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019383410.3390/jcm9030834jcm9030834Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term EquivalenceColleen Peyton0Christa Einspieler1Toril Fjørtoft2Lars Adde3Michael D. Schreiber4Alexander Drobyshevsky5Jeremy D. Marks6Department of Pediatrics, University of Chicago, Chicago, IL 60422, USAResearch Unit IDN, Interdisciplinary Developmental Neuroscience, Division of Phoniatrics, Medical University of Graz, Graz 8036, AustriaDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Pediatrics, University of Chicago, Chicago, IL 60422, USADepartment of Pediatrics, NorthShore University HealthSystem, Evanston, IL 60201, USADepartment of Pediatrics, University of Chicago, Chicago, IL 60422, USAPreterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-term age is associated with neurodevelopmental impairment. We imaged brain blood oxygen level-dependent signals at term-equivalent age in 62 infants born at <32 weeks gestation and explored whether resting state functional connectivity (rsFC) differed with performances on the General Movement Assessment (GMA) at 12−15 weeks, and Bayley III scores at two years of corrected age. Infants with aberrant general movements exhibited decreased rsFC between the basal ganglia and regions in parietal and frontotemporal lobes. Infants with normal Bayley III cognitive scores exhibited increased rsFC between the basal ganglia and association cortices in parietal and occipital lobes compared with cognitively impaired children. Infants with normal motor scores exhibited increased rsFC between the basal ganglia and visual cortices, compared with children with motor impairment. Thus, the presence of abnormal general movements is associated with region-specific differences in rsFC at term. The association of abnormal long-term neurodevelopmental outcomes with decreased rsFC between basal ganglia and sub-score specific cortical regions may provide biomarkers of neurodevelopmental trajectory and outcome.https://www.mdpi.com/2077-0383/9/3/834general movementsperinatal brain injuryfunctional brain connectivitypreterm infantbayley scalefidgety movements |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Colleen Peyton Christa Einspieler Toril Fjørtoft Lars Adde Michael D. Schreiber Alexander Drobyshevsky Jeremy D. Marks |
spellingShingle |
Colleen Peyton Christa Einspieler Toril Fjørtoft Lars Adde Michael D. Schreiber Alexander Drobyshevsky Jeremy D. Marks Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence Journal of Clinical Medicine general movements perinatal brain injury functional brain connectivity preterm infant bayley scale fidgety movements |
author_facet |
Colleen Peyton Christa Einspieler Toril Fjørtoft Lars Adde Michael D. Schreiber Alexander Drobyshevsky Jeremy D. Marks |
author_sort |
Colleen Peyton |
title |
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence |
title_short |
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence |
title_full |
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence |
title_fullStr |
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence |
title_full_unstemmed |
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence |
title_sort |
correlates of normal and abnormal general movements in infancy and long-term neurodevelopment of preterm infants: insights from functional connectivity studies at term equivalence |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-term age is associated with neurodevelopmental impairment. We imaged brain blood oxygen level-dependent signals at term-equivalent age in 62 infants born at <32 weeks gestation and explored whether resting state functional connectivity (rsFC) differed with performances on the General Movement Assessment (GMA) at 12−15 weeks, and Bayley III scores at two years of corrected age. Infants with aberrant general movements exhibited decreased rsFC between the basal ganglia and regions in parietal and frontotemporal lobes. Infants with normal Bayley III cognitive scores exhibited increased rsFC between the basal ganglia and association cortices in parietal and occipital lobes compared with cognitively impaired children. Infants with normal motor scores exhibited increased rsFC between the basal ganglia and visual cortices, compared with children with motor impairment. Thus, the presence of abnormal general movements is associated with region-specific differences in rsFC at term. The association of abnormal long-term neurodevelopmental outcomes with decreased rsFC between basal ganglia and sub-score specific cortical regions may provide biomarkers of neurodevelopmental trajectory and outcome. |
topic |
general movements perinatal brain injury functional brain connectivity preterm infant bayley scale fidgety movements |
url |
https://www.mdpi.com/2077-0383/9/3/834 |
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