Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence

Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-ter...

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Main Authors: Colleen Peyton, Christa Einspieler, Toril Fjørtoft, Lars Adde, Michael D. Schreiber, Alexander Drobyshevsky, Jeremy D. Marks
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/9/3/834
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spelling doaj-5424205f41c74bc7a3acee186f9df9972020-11-25T01:41:51ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019383410.3390/jcm9030834jcm9030834Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term EquivalenceColleen Peyton0Christa Einspieler1Toril Fjørtoft2Lars Adde3Michael D. Schreiber4Alexander Drobyshevsky5Jeremy D. Marks6Department of Pediatrics, University of Chicago, Chicago, IL 60422, USAResearch Unit IDN, Interdisciplinary Developmental Neuroscience, Division of Phoniatrics, Medical University of Graz, Graz 8036, AustriaDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Pediatrics, University of Chicago, Chicago, IL 60422, USADepartment of Pediatrics, NorthShore University HealthSystem, Evanston, IL 60201, USADepartment of Pediatrics, University of Chicago, Chicago, IL 60422, USAPreterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-term age is associated with neurodevelopmental impairment. We imaged brain blood oxygen level-dependent signals at term-equivalent age in 62 infants born at <32 weeks gestation and explored whether resting state functional connectivity (rsFC) differed with performances on the General Movement Assessment (GMA) at 12−15 weeks, and Bayley III scores at two years of corrected age. Infants with aberrant general movements exhibited decreased rsFC between the basal ganglia and regions in parietal and frontotemporal lobes. Infants with normal Bayley III cognitive scores exhibited increased rsFC between the basal ganglia and association cortices in parietal and occipital lobes compared with cognitively impaired children. Infants with normal motor scores exhibited increased rsFC between the basal ganglia and visual cortices, compared with children with motor impairment. Thus, the presence of abnormal general movements is associated with region-specific differences in rsFC at term. The association of abnormal long-term neurodevelopmental outcomes with decreased rsFC between basal ganglia and sub-score specific cortical regions may provide biomarkers of neurodevelopmental trajectory and outcome.https://www.mdpi.com/2077-0383/9/3/834general movementsperinatal brain injuryfunctional brain connectivitypreterm infantbayley scalefidgety movements
collection DOAJ
language English
format Article
sources DOAJ
author Colleen Peyton
Christa Einspieler
Toril Fjørtoft
Lars Adde
Michael D. Schreiber
Alexander Drobyshevsky
Jeremy D. Marks
spellingShingle Colleen Peyton
Christa Einspieler
Toril Fjørtoft
Lars Adde
Michael D. Schreiber
Alexander Drobyshevsky
Jeremy D. Marks
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
Journal of Clinical Medicine
general movements
perinatal brain injury
functional brain connectivity
preterm infant
bayley scale
fidgety movements
author_facet Colleen Peyton
Christa Einspieler
Toril Fjørtoft
Lars Adde
Michael D. Schreiber
Alexander Drobyshevsky
Jeremy D. Marks
author_sort Colleen Peyton
title Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
title_short Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
title_full Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
title_fullStr Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
title_full_unstemmed Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
title_sort correlates of normal and abnormal general movements in infancy and long-term neurodevelopment of preterm infants: insights from functional connectivity studies at term equivalence
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2020-03-01
description Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12−15 weeks post-term age is associated with neurodevelopmental impairment. We imaged brain blood oxygen level-dependent signals at term-equivalent age in 62 infants born at <32 weeks gestation and explored whether resting state functional connectivity (rsFC) differed with performances on the General Movement Assessment (GMA) at 12−15 weeks, and Bayley III scores at two years of corrected age. Infants with aberrant general movements exhibited decreased rsFC between the basal ganglia and regions in parietal and frontotemporal lobes. Infants with normal Bayley III cognitive scores exhibited increased rsFC between the basal ganglia and association cortices in parietal and occipital lobes compared with cognitively impaired children. Infants with normal motor scores exhibited increased rsFC between the basal ganglia and visual cortices, compared with children with motor impairment. Thus, the presence of abnormal general movements is associated with region-specific differences in rsFC at term. The association of abnormal long-term neurodevelopmental outcomes with decreased rsFC between basal ganglia and sub-score specific cortical regions may provide biomarkers of neurodevelopmental trajectory and outcome.
topic general movements
perinatal brain injury
functional brain connectivity
preterm infant
bayley scale
fidgety movements
url https://www.mdpi.com/2077-0383/9/3/834
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