ApoE and cerebral insulin: Trafficking, receptors, and resistance

ApoE and cerebral insulin: Trafficking, receptors, and resistance

Central nervous system (CNS) insulin resistance is associated with Alzheimer's disease (AD). In addition, the apolipoprotein E4 (apoE4) isoform is a risk factor for AD. The connection between these two factors in relation to AD is being actively explored. We summarize this literature with a foc...

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Bibliographic Details
Main Authors: Elizabeth M. Rhea, Jacob Raber, William A. Banks
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E
Central nervous system insulin
Insulin receptor
Blood-brain barrier
Alzheimer's disease
Amyloid beta
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300309

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http://www.sciencedirect.com/science/article/pii/S0969996120300309

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