STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.

Bibliographic Details
Main Authors: Hongxu Xian, Qiaoyun Yang, Lin Xiao, Han-Ming Shen, Yih-Cherng Liou
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10096-1
id doaj-541fac42676e41b1a63f6626d9812ae1
record_format Article
spelling doaj-541fac42676e41b1a63f6626d9812ae12021-05-11T12:37:12ZengNature Publishing GroupNature Communications2041-17232019-05-0110111710.1038/s41467-019-10096-1STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanismHongxu Xian0Qiaoyun Yang1Lin Xiao2Han-Ming Shen3Yih-Cherng Liou4Department of Biological Sciences, Faculty of Science, National University of SingaporeDepartment of Biological Sciences, Faculty of Science, National University of SingaporeDepartment of Biological Sciences, Faculty of Science, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Biological Sciences, Faculty of Science, National University of SingaporeMitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.https://doi.org/10.1038/s41467-019-10096-1
collection DOAJ
language English
format Article
sources DOAJ
author Hongxu Xian
Qiaoyun Yang
Lin Xiao
Han-Ming Shen
Yih-Cherng Liou
spellingShingle Hongxu Xian
Qiaoyun Yang
Lin Xiao
Han-Ming Shen
Yih-Cherng Liou
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
Nature Communications
author_facet Hongxu Xian
Qiaoyun Yang
Lin Xiao
Han-Ming Shen
Yih-Cherng Liou
author_sort Hongxu Xian
title STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_short STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_full STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_fullStr STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_full_unstemmed STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_sort stx17 dynamically regulated by fis1 induces mitophagy via hierarchical macroautophagic mechanism
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-05-01
description Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.
url https://doi.org/10.1038/s41467-019-10096-1
work_keys_str_mv AT hongxuxian stx17dynamicallyregulatedbyfis1inducesmitophagyviahierarchicalmacroautophagicmechanism
AT qiaoyunyang stx17dynamicallyregulatedbyfis1inducesmitophagyviahierarchicalmacroautophagicmechanism
AT linxiao stx17dynamicallyregulatedbyfis1inducesmitophagyviahierarchicalmacroautophagicmechanism
AT hanmingshen stx17dynamicallyregulatedbyfis1inducesmitophagyviahierarchicalmacroautophagicmechanism
AT yihcherngliou stx17dynamicallyregulatedbyfis1inducesmitophagyviahierarchicalmacroautophagicmechanism
_version_ 1721444468182220800

Similar Items