MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated p...

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Bibliographic Details
Main Authors: Lin Shibo, Hoffmann Katrin, Xiao Zhi, Jin Nan, Galli Uwe, Mohr Elvira, Büchler Markus W, Schemmer Peter
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
MEK
MRP1
MRP3
Multidrug resistance
Online Access:http://www.cancerci.com/content/13/1/3

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