RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA studies, we investigated RRM2B alterations in cancer. We found that RRM2B is...

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Bibliographic Details
Main Authors: Waleed Iqbal, Elena V. Demidova, Samantha Serrao, Taha ValizadehAslani, Gail Rosen, Sanjeevani Arora
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
chromosome 8
8q-amplicon
RRM2B
cancer
MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.628758/full

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