Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle

Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle

During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1−/− mice possess severe d...

Full description

Bibliographic Details
Main Authors: Valery I. Shestopalov, Yuri Panchin, Olga S. Tarasova, Dina Gaynullina, Vladimir M. Kovalzon
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
pannexins
non-REM sleep
purinergic system
cytokines
prostaglandin D2
glymphatic system
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00210/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00210/full

Similar Items