The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.

The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic prog...

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Bibliographic Details
Main Authors: Xi Liu, Hao Yuan, Laurent Peres, Saijuan Chen, Zhu Chen, Hugues de The, Jun Zhou, Jun Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4131979?pdf=render

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http://europepmc.org/articles/PMC4131979?pdf=render

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