Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and γ-schisandrin (γ-Sch), the inhibitory action of SchB might result from a stereospeci...

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Bibliographic Details
Main Authors:	Naoto Tatewaki, Hiroshi Nishida, Masaaki Yoshida, Hidehiro Ando, Seizo Kondo, Toshiyuki Sakamaki, Tetsuya Konishi
Format:	Article
Language:	English
Published:	Elsevier 2013-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319303317

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