Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases

Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because i...

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Main Authors:	Md. Jakaria, Joonsoo Kim, Govindarajan Karthivashan, Shin-Young Park, Palanivel Ganesan, Dong-Kug Choi
Format:	Article
Language:	English
Published:	Elsevier 2019-04-01
Series:	Journal of Ginseng Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1226845317302208

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spelling	doaj-53ee05d0cf554773890837d3331cac4b2020-11-25T00:54:42ZengElsevierJournal of Ginseng Research1226-84532019-04-01432163171Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseasesMd. Jakaria0Joonsoo Kim1Govindarajan Karthivashan2Shin-Young Park3Palanivel Ganesan4Dong-Kug Choi5Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaResearch Institute of Inflammatory Disease, and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaResearch Institute of Inflammatory Disease, and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea; Nanotechnology Research Center, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of Korea; Research Institute of Inflammatory Disease, and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea; Nanotechnology Research Center, Konkuk University, Chungju, Republic of Korea; Corresponding author. Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea.Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have found that various ion channels and specific signaling pathways might have contributed to the disease pathogenesis. Apart from the different pharmacological potentials, ginseng and its active compounds modulate various ion channels and specific molecular signaling pathways related to the nervous system. Here, we discuss the signal modulating potential of ginseng and its active compounds mainly focusing on those relevant to NDDs. Keywords: Active compounds, Ginseng, Ion channels, Neurodegenerative diseases, Signaling pathwayhttp://www.sciencedirect.com/science/article/pii/S1226845317302208
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Md. Jakaria Joonsoo Kim Govindarajan Karthivashan Shin-Young Park Palanivel Ganesan Dong-Kug Choi
spellingShingle	Md. Jakaria Joonsoo Kim Govindarajan Karthivashan Shin-Young Park Palanivel Ganesan Dong-Kug Choi Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases Journal of Ginseng Research
author_facet	Md. Jakaria Joonsoo Kim Govindarajan Karthivashan Shin-Young Park Palanivel Ganesan Dong-Kug Choi
author_sort	Md. Jakaria
title	Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
title_short	Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
title_full	Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
title_fullStr	Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
title_full_unstemmed	Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
title_sort	emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
publisher	Elsevier
series	Journal of Ginseng Research
issn	1226-8453
publishDate	2019-04-01
description	Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have found that various ion channels and specific signaling pathways might have contributed to the disease pathogenesis. Apart from the different pharmacological potentials, ginseng and its active compounds modulate various ion channels and specific molecular signaling pathways related to the nervous system. Here, we discuss the signal modulating potential of ginseng and its active compounds mainly focusing on those relevant to NDDs. Keywords: Active compounds, Ginseng, Ion channels, Neurodegenerative diseases, Signaling pathway
url	http://www.sciencedirect.com/science/article/pii/S1226845317302208
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Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases

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