Сlinical, functional and morphological results of diabetic macular edema antiangiogenic treatment in patients with diabetes mellitus type two

• Main Authors: L. K. Moshetova, I. V. Vorobieva, E. V. Parfenova, D. A. Merkushenkova, P. I. Makarevich, V. I. Alekhnovich
• Format: Article
• Language: Russian
• Published: Ophthalmology Publishing Group 2014-07-01
• Series: Oftalʹmologiâ
• Subjects: diabetic macular edema; angiogenesis inhibitor; VEGF
• Online Access: http://www.ophthalmojournal.com/index.php/opht/article/view/54

<p><strong>Purpose:</strong> To evaluate of retinal morphology and function progress in patients with diabetes type 2 and DME consistent with the level of pathogenetic factor in tear fluid.</p><p><br /><strong>Methods:</strong> The progress of visual acuity, retinal thickness and photosensitivity after ranibizumab intravitreal injection has been assessed.</p><p><br /><strong>Results</strong>: Statistically significant increase in visual acuity, retinal photosensitivity, decrease of retinal thickness and VEGF A level was found in the tear fluid after injection. The correlation of VEGF level in tear fluid with visual acuity after procedure was found to be negative. </p><p><br /><strong>Conclusion:</strong> Ranibizumab intravitreal injection is a pathogenic treatment leading to morphological and functional retinal state improvement.</p>