Involvement of the modifier gene of a human Mendelian disorder in a negative selection process.

Involvement of the modifier gene of a human Mendelian disorder in a negative selection process.

BACKGROUND:Identification of modifier genes and characterization of their effects represent major challenges in human genetics. SAA1 is one of the few modifiers identified in humans: this gene influences the risk of renal amyloidosis (RA) in patients with familial Mediterranean fever (FMF), a Mendel...

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Main Authors: Isabelle Jéru, Hasmik Hayrapetyan, Philippe Duquesnoy, Emmanuelle Cochet, Jean-Louis Serre, Josué Feingold, Gilles Grateau, Tamara Sarkisian, Marc Jeanpierre, Serge Amselem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2765618?pdf=render

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