A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-...

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Bibliographic Details
Main Authors: Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Neurobiology of Disease
Subjects:
Autophagy
mTOR complex (mTORC)
CRMP2
DPYSL2
Lanthionine ketimine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000698

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