Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage.

Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage.

The transcription factor SOX2 has been identified as a lineage survival oncogene in squamous cell carcinoma and copy number gain is a common event in several human malignancies including head and neck cancer. However, the regulation and function of SOX2 during carcinogenesis as well as its prognosti...

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Bibliographic Details
Main Authors: Julia Thierauf, Stephanie E Weissinger, Johannes A Veit, Annette Affolter, Natalia K Laureano, Dirk Beutner, Gregor Heiduschka, Lorenz Kadletz, Moritz Meyer, Alexander Quaas, Peter Plinkert, Thomas K Hoffmann, Jochen Hess
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5875788?pdf=render

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