Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands
Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile tha...
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Bibliographic Details
| Main Authors: |
Richard Peter Owen,
Michael Joseph White,
David Tyler Severson,
Barbara Braden,
Adam Bailey,
Robert Goldin,
Lai Mun Wang,
Carlos Ruiz-Puig,
Nicholas David Maynard,
Angie Green,
Paolo Piazza,
David Buck,
Mark Ross Middleton,
Chris Paul Ponting,
Benjamin Schuster-Böckler,
Xin Lu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-06796-9
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