Miglitol, an Anti-diabetic Drug, Inhibits Oxidative Stress–Induced Apoptosis and Mitochondrial ROS Over-Production in Endothelial Cells by Enhancement of AMP-Activated Protein Kinase

Miglitol, an Anti-diabetic Drug, Inhibits Oxidative Stress–Induced Apoptosis and Mitochondrial ROS Over-Production in Endothelial Cells by Enhancement of AMP-Activated Protein Kinase

Endothelial dysfunction caused by oxidative stress plays a key role in atherogenesis. This study investigated whether the anti-diabetic drug miglitol, an α-glucosidase inhibitor, which is currently available in clinical practice, can prevent endothelial cell apoptosis and whether it might restore im...

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Bibliographic Details
Main Authors: Chie Aoki, Kunihiro Suzuki, Kazunori Yanagi, Hiroko Satoh, Mai Niitani, Yoshimasa Aso
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319304505

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