Treatment Emergent Agranulocytosis with Skin and Gingival Lesions in a Chronic Lymphocytic Leukemia Patient: A Case Report
Chronic Lymphocytic Leukaemia (CLL) is a monoclonal lymphoid malignancy characterized by progressive accumulation of small, mature but functionally incompetent neoplastic lymphocytes in the peripheral blood, bone marrow and lymphoid organs. Patients present a variable course and may not require ea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8662/21334_CE(Ra1)_F(AK)_PF1(T_NE)_PFA(AK)_PF2(EKAK).pdf |
| Summary: | Chronic Lymphocytic Leukaemia (CLL) is a monoclonal lymphoid malignancy characterized by progressive accumulation of small,
mature but functionally incompetent neoplastic lymphocytes in the peripheral blood, bone marrow and lymphoid organs. Patients
present a variable course and may not require early intervention unlike other malignancies. Patients with rapidly deteriorating blood
counts, and organomegaly need treatment. Alkylating agent live Bendamustine combined with Rituximab, anti-CD 20 monoclonal
antibody have shown promising results in such patients. Anaemia, neutropenia and thrombocytopenia have been reported as treatment
emergent events with this combination therapy. Neutrophils are the major innate defense and their depletion can result in a wide range
of opportunistic infections. This case report discusess the oral and dermal lesions which emerged with the Rituximab and Bendamustine
combination therapy in a patient with CLL and their management. |
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| ISSN: | 2249-782X 0973-709X |