The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

Pentapeptides having the sequence R-HN-Ala-Val-X-Val-Leu-OMe, where the central residue X is L-serine, L-threonine, (2S,3R)-L-CF3-threonine and (2S,3S)-L-CF3-threonine were prepared. The capacity of (2S,3S)- and (2S,3R)-CF3-threonine analogues to stabilize an extended structure when introduced in th...

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Bibliographic Details
Main Authors: Yaochun Xu, Isabelle Correia, Tap Ha-Duong, Nadjib Kihal, Jean-Louis Soulier, Julia Kaffy, Benoît Crousse, Olivier Lequin, Sandrine Ongeri
Format: Article
Language:English
Published: Beilstein-Institut 2017-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aggregation
beta-sheet
fluorine
peptide
unnatural amino acid
Online Access:https://doi.org/10.3762/bjoc.13.276

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