MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.

MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.

Human embryonic stem cells (hESCs) can potentially differentiate into any cell type, including dopaminergic neurons to treat Parkinson's disease (PD), but hyperproliferation and tumor formation must be avoided. Accordingly, we use myocyte enhancer factor 2C (MEF2C) as a neurogenic and anti-apop...

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Bibliographic Details
Main Authors: Eun-Gyung Cho, Jeffrey D Zaremba, Scott R McKercher, Maria Talantova, Shichun Tu, Eliezer Masliah, Shing Fai Chan, Nobuki Nakanishi, Alexey Terskikh, Stuart A Lipton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21901155/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21901155/?tool=EBI

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