Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment

Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment

After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 from rod PRs results in a more rapid death of these cells afte...

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Bibliographic Details
Main Authors: Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
retinal detachment
HMGB1
photoreceptor
autophagy
apoptosis
Online Access:https://www.mdpi.com/2073-4409/10/8/2010

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