Clinical and morphological features of peptic ulcer at men and women

• Main Authors: Islamova Е.А., Lipatova Т.Е.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2010-09-01
• Series: Саратовский научно-медицинский журнал
• Subjects: endocrine cells; men; peptic ulcer; sexual hormone receptors; women
• Online Access: http://www.ssmj.ru/system/files/201003_575_579.pdf

The aim of research was to study clinical and morphological features of peptic ulcer at men and women of various age. 166 patients with duodenal peptic ulcer (80 men and 86 women) and 138 with stomach peptic ulcer (80 men and 58 women) were inspected. Clinical displays, morphometrical analysis of components of diffuse neuroendocrine system and stomach receptors of sexual hormones were studied. It is defined, that peptic ulcer at women under 40 years has more favorable clinical current, than at men. This is based on local neuroendocrine status with positive shifts of melatonin-, VEGF-, glucagon-like cells. In patients aged upwards 40 clinical features of disease course, local neuroendocrine status are erased both at men and women. In patho-genesis of peptic ulcer infringement of receptors expression of steroid hormones in stomach with hyper expression of androgen receptors at men or decrease in receptors expression of estrogen and progesterone along with increase of expression of androgen receptors at women matters. Forecasting of peptic ulcer can be based not only on traditional criteria, but also on results of dynamic research of androgen receptors expression (at men), androgen-, estrogen and progesterone receptors (at women)