Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives

• Main Authors: Popat B. Mohite, V. H. Bhaskar
• Format: Article
• Language: English
• Published: Universidade Federal de Mato Grosso do Sul 2011-09-01
• Series: Orbital: The Electronic Journal of Chemistry
• Subjects: 1,3,4-oxadiazole; tetrazole; antimicrobial activity
• Online Access: http://orbital.ufms.br/index.php/Chemistry/article/view/225

<div>In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activities of various novel 1,3,4-oxadiazole containing 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl)acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff’s bases with acetic anhydride results in 1,3,4-oxadiazole derivatives. The structures of the newly synthesized 1,3,4-oxadiazole were confirmed by FT-IR, 1H NMR and mass spectral data. The antimicrobial activity was determined by MIC method. All the compounds exhibited weak to potent antimicrobial activity. Some derivatives bearing a methoxy group exhibited very good antimicrobial activity at conc. of 62.5 µg/mL.</div>