Structural basis for the reaction cycle of DASS dicarboxylate transporters

Structural basis for the reaction cycle of DASS dicarboxylate transporters

Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential roles in metabolic signaling and cellular regulation. These di- and tricarboxylates are imported into the cell by the divalent anion sodium symporter (DASS) family of plasma membrane transporters, which conta...

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Bibliographic Details
Main Authors: David B Sauer, Noah Trebesch, Jennifer J Marden, Nicolette Cocco, Jinmei Song, Akiko Koide, Shohei Koide, Emad Tajkhorshid, Da-Neng Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
membrane transport
membrane protein structure
cryo-EM
X-ray crystallography
Vibrio cholerae
Lactobacillus acidophilus
Online Access:https://elifesciences.org/articles/61350

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