Small Molecules Present in the Cerebrospinal Fluid Metabolome Influence Superoxide Dismutase 1 Aggregation

Small Molecules Present in the Cerebrospinal Fluid Metabolome Influence Superoxide Dismutase 1 Aggregation

Superoxide dismutase 1 (SOD1) aggregation is one of the pathological markers of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. The underlying molecular grounds of SOD1 pathologic aggregation remains obscure as mutations alone are not exclusively the cause for the formation...

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Bibliographic Details
Main Authors: Isabel Cardoso, Joana S. Cristóvão, Cláudio M. Gomes, Sónia S. Leal
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
protein aggregation
amyloid
neurodegeneration
nanoparticle tracking analysis
transmission electron microscopy
dynamic light scattering
small molecules
Online Access:http://www.mdpi.com/1422-0067/14/9/19128

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