Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency

Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency

Glucose 6 phosphate dehydrogenase (G6PD) is a housekeeping enzyme critical in the redox metabolism. In red blood cells, it is the only source of Nicotinamide adenine dinucleotide phosphate hydrogen(NADPH) that act directly and via glutathione defends these cells against oxidative stress. Dengue infe...

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Main Authors: R. Arujun, T. Kumanan, V. Sujanitha, T. Sooriyakumar, R. M. U. K. B. Ratnayake, A. Anuruththan
Format: Article
Language:English
Published: The Kandy Society of Medicine 2019-12-01
Series:Sri Lanka Journal of Medicine
Subjects:
glucose 6 phosphate dehydrogenase , methemoglobinaemia, rhabdomyolysis
Online Access:https://sljm.sljol.info/articles/127
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spelling doaj-538f3cf2dfb24003bd52a6a5f37b1bd52020-11-25T02:17:54ZengThe Kandy Society of MedicineSri Lanka Journal of Medicine 2579-19902019-12-01282758010.4038/sljm.v28i2.12779Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiencyR. Arujun0T. Kumanan1V. Sujanitha2T. Sooriyakumar3R. M. U. K. B. Ratnayake4A. Anuruththan5Teaching Hospital JaffnaTeaching Hospital JaffnaTeaching Hospital JaffnaTeaching Hospital JaffnaTeaching Hospital JaffnaTeaching Hospital JaffnaGlucose 6 phosphate dehydrogenase (G6PD) is a housekeeping enzyme critical in the redox metabolism. In red blood cells, it is the only source of Nicotinamide adenine dinucleotide phosphate hydrogen(NADPH) that act directly and via glutathione defends these cells against oxidative stress. Dengue infection as like other infections can trigger intravascular haemolysis in G6PD deficiency patients. We have reported a 17 year old boy with G6PD deficiency presented with dengue fever which was complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis.https://sljm.sljol.info/articles/127glucose 6 phosphate dehydrogenase , methemoglobinaemia, rhabdomyolysis
collection DOAJ
language English
format Article
sources DOAJ
author R. Arujun
T. Kumanan
V. Sujanitha
T. Sooriyakumar
R. M. U. K. B. Ratnayake
A. Anuruththan
spellingShingle R. Arujun
T. Kumanan
V. Sujanitha
T. Sooriyakumar
R. M. U. K. B. Ratnayake
A. Anuruththan
Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
Sri Lanka Journal of Medicine
glucose 6 phosphate dehydrogenase , methemoglobinaemia, rhabdomyolysis
author_facet R. Arujun
T. Kumanan
V. Sujanitha
T. Sooriyakumar
R. M. U. K. B. Ratnayake
A. Anuruththan
author_sort R. Arujun
title Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
title_short Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
title_full Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
title_fullStr Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
title_full_unstemmed Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency
title_sort dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with g6pd deficiency
publisher The Kandy Society of Medicine
series Sri Lanka Journal of Medicine
issn 2579-1990
publishDate 2019-12-01
description Glucose 6 phosphate dehydrogenase (G6PD) is a housekeeping enzyme critical in the redox metabolism. In red blood cells, it is the only source of Nicotinamide adenine dinucleotide phosphate hydrogen(NADPH) that act directly and via glutathione defends these cells against oxidative stress. Dengue infection as like other infections can trigger intravascular haemolysis in G6PD deficiency patients. We have reported a 17 year old boy with G6PD deficiency presented with dengue fever which was complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis.
topic glucose 6 phosphate dehydrogenase , methemoglobinaemia, rhabdomyolysis
url https://sljm.sljol.info/articles/127
work_keys_str_mv AT rarujun denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
AT tkumanan denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
AT vsujanitha denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
AT tsooriyakumar denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
AT rmukbratnayake denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
AT aanuruththan denguecomplicatedbyacutehaemolysismethaemoglobinemiahepatitisandrhabdomyolysisinapatientwithg6pddeficiency
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