Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice

Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice

Metabolic disease risk escalates following menopause. The mechanism is not fully known, but likely involves reduced signaling through estrogen receptor alpha (ERα), which is highly expressed in brown and white adipose tissue (BAT and WAT).Objective: Test the hypothesis that uncoupling protein (UCP1)...

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Bibliographic Details
Main Authors: Stephanie L. Clookey, Rebecca J. Welly, Dusti Shay, Makenzie L. Woodford, Kevin L. Fritsche, R. Scott Rector, Jaume Padilla, Dennis B. Lubahn, Victoria J. Vieira-Potter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
adipose tissue
energy expenditure
browning
insulin resistance
high fat diet
CL 316
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00009/full

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