Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

<p>Abstract</p> <p>Background</p> <p>Increased expression of the pro-fibrotic protein connective tissue growth factor (CTGF) has been detected in injured kidneys and elevated urinary levels of CTGF are discussed as prognostic marker of chronic kidney disease. There is e...

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Bibliographic Details
Main Authors: Zuehlke Jonathan, Ebenau Astrid, Krueger Bettina, Goppelt-Struebe Margarete
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Cell Communication and Signaling
Subjects:
Connective tissue growth factor
Primary human tubular epithelial cells
Transforming growth factor β
Lysophosphatidic acid
Vectorial secretion
Cell polarization
Online Access:http://www.biosignaling.com/content/10/1/25

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