Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.

Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days). Rats were divided into control, ghreli...

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Main Authors: Hyung Jin Choi, Kyoung Ho Ki, Jae-Yeon Yang, Bo Young Jang, Jung Ah Song, Wook-Young Baek, Jung Hee Kim, Jee Hyun An, Sang Wan Kim, Seong Yeon Kim, Jung-Eun Kim, Chan Soo Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699588?pdf=render
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spelling doaj-53831d531a0742b8b0faff3df8f4a9682020-11-24T21:56:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6550510.1371/journal.pone.0065505Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.Hyung Jin ChoiKyoung Ho KiJae-Yeon YangBo Young JangJung Ah SongWook-Young BaekJung Hee KimJee Hyun AnSang Wan KimSeong Yeon KimJung-Eun KimChan Soo ShinLeptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days). Rats were divided into control, ghrelin ad libitum-fed (ghrelin ad lib-fed), and ghrelin pair-fed groups. Ghrelin intracerebroventricular infusion significantly increased body weight in ghrelin ad lib-fed rats but not in ghrelin pair-fed rats, as compared with control rats. Chronic intracerebroventricular ghrelin infusion significantly increased bone mass in the ghrelin pair-fed group compared with control as indicated by increased bone volume percentage, trabecular thickness, trabecular number and volumetric bone mineral density in tibia trabecular bone. There was no significant difference in trabecular bone mass between the control group and the ghrelin ad-lib fed group. Chronic intracerebroventricular ghrelin infusion significantly increased the mineral apposition rate in the ghrelin pair-fed group as compared with control. In conclusion, chronic central administration of ghrelin increases bone mass through a mechanism that is independent of body weight, suggesting that ghrelin may have a bone anabolic effect through the central nervous system.http://europepmc.org/articles/PMC3699588?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Hyung Jin Choi
Kyoung Ho Ki
Jae-Yeon Yang
Bo Young Jang
Jung Ah Song
Wook-Young Baek
Jung Hee Kim
Jee Hyun An
Sang Wan Kim
Seong Yeon Kim
Jung-Eun Kim
Chan Soo Shin
spellingShingle Hyung Jin Choi
Kyoung Ho Ki
Jae-Yeon Yang
Bo Young Jang
Jung Ah Song
Wook-Young Baek
Jung Hee Kim
Jee Hyun An
Sang Wan Kim
Seong Yeon Kim
Jung-Eun Kim
Chan Soo Shin
Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
PLoS ONE
author_facet Hyung Jin Choi
Kyoung Ho Ki
Jae-Yeon Yang
Bo Young Jang
Jung Ah Song
Wook-Young Baek
Jung Hee Kim
Jee Hyun An
Sang Wan Kim
Seong Yeon Kim
Jung-Eun Kim
Chan Soo Shin
author_sort Hyung Jin Choi
title Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
title_short Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
title_full Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
title_fullStr Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
title_full_unstemmed Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.
title_sort chronic central administration of ghrelin increases bone mass through a mechanism independent of appetite regulation.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days). Rats were divided into control, ghrelin ad libitum-fed (ghrelin ad lib-fed), and ghrelin pair-fed groups. Ghrelin intracerebroventricular infusion significantly increased body weight in ghrelin ad lib-fed rats but not in ghrelin pair-fed rats, as compared with control rats. Chronic intracerebroventricular ghrelin infusion significantly increased bone mass in the ghrelin pair-fed group compared with control as indicated by increased bone volume percentage, trabecular thickness, trabecular number and volumetric bone mineral density in tibia trabecular bone. There was no significant difference in trabecular bone mass between the control group and the ghrelin ad-lib fed group. Chronic intracerebroventricular ghrelin infusion significantly increased the mineral apposition rate in the ghrelin pair-fed group as compared with control. In conclusion, chronic central administration of ghrelin increases bone mass through a mechanism that is independent of body weight, suggesting that ghrelin may have a bone anabolic effect through the central nervous system.
url http://europepmc.org/articles/PMC3699588?pdf=render
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