STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY

Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value. Material and methods. Amino acid pools were studied...

Full description

Bibliographic Details
Main Authors:	Doroshenko Ye. M., Snezhitsky V. A., Lelevich V. V.
Format:	Article
Language:	Belarusian
Published:	Grodno State Medical University 2017-12-01
Series:	Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
Subjects:	amino acids tryptophan serotonin homocysteine taurine ishemic heart disease chronic heart insufficiency
Online Access:	http://journal-grsmu.by/index.php/ojs/article/view/2200/2019

id	doaj-537ac6481229464a8f154c761332750a
record_format	Article
spelling	doaj-537ac6481229464a8f154c761332750a2020-11-24T23:46:20ZbelGrodno State Medical University Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092017-12-0115555155610.25298/2221-8785-2017-15-5-551-556STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY Doroshenko Ye. M.0Snezhitsky V. A.1Lelevich V. V.2Educational Institution “Grodno State Medical University”Educational Institution “Grodno State Medical University”Educational Institution «Grodno State Medical University»Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value. Material and methods. Amino acid pools were studied by high-performance liquid chromatography in plasma of 45 patients with IHD including 20 patients with CHI and 30 healthy persons. Results. Hyperhomocysteinemia is distinctive for patients with CHI only. Changes in levels of compounds related to amino acid transport to cells (decreased content of total cysteinylglycine, increased – of total cysteine and glutathione) were seen even in absence of CHI. Increased level of serotonin and decreased – of tryptophan in plasma were observed regardless of the CHI. Conclusion. Manifestation of CHI can substantially aggravate the amino acid imbalance existing in blood plasma of patients with IHD.http://journal-grsmu.by/index.php/ojs/article/view/2200/2019amino acidstryptophanserotoninhomocysteinetaurineishemic heart diseasechronic heart insufficiency
collection	DOAJ
language	Belarusian
format	Article
sources	DOAJ
author	Doroshenko Ye. M. Snezhitsky V. A. Lelevich V. V.
spellingShingle	Doroshenko Ye. M. Snezhitsky V. A. Lelevich V. V. STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta amino acids tryptophan serotonin homocysteine taurine ishemic heart disease chronic heart insufficiency
author_facet	Doroshenko Ye. M. Snezhitsky V. A. Lelevich V. V.
author_sort	Doroshenko Ye. M.
title	STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY
title_short	STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY
title_full	STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY
title_fullStr	STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY
title_full_unstemmed	STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY
title_sort	structure of the pool of free amino acids and their derivatives in plasma of patients with ishemic heart disease and chronic cardiac insufficiency
publisher	Grodno State Medical University
series	Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta
issn	2221-8785 2413-0109
publishDate	2017-12-01
description	Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value. Material and methods. Amino acid pools were studied by high-performance liquid chromatography in plasma of 45 patients with IHD including 20 patients with CHI and 30 healthy persons. Results. Hyperhomocysteinemia is distinctive for patients with CHI only. Changes in levels of compounds related to amino acid transport to cells (decreased content of total cysteinylglycine, increased – of total cysteine and glutathione) were seen even in absence of CHI. Increased level of serotonin and decreased – of tryptophan in plasma were observed regardless of the CHI. Conclusion. Manifestation of CHI can substantially aggravate the amino acid imbalance existing in blood plasma of patients with IHD.
topic	amino acids tryptophan serotonin homocysteine taurine ishemic heart disease chronic heart insufficiency
url	http://journal-grsmu.by/index.php/ojs/article/view/2200/2019
work_keys_str_mv	AT doroshenkoyem structureofthepooloffreeaminoacidsandtheirderivativesinplasmaofpatientswithishemicheartdiseaseandchroniccardiacinsufficiency AT snezhitskyva structureofthepooloffreeaminoacidsandtheirderivativesinplasmaofpatientswithishemicheartdiseaseandchroniccardiacinsufficiency AT lelevichvv structureofthepooloffreeaminoacidsandtheirderivativesinplasmaofpatientswithishemicheartdiseaseandchroniccardiacinsufficiency
_version_	1725493709902970880

STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY

Similar Items