Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

Diabetic peripheral neuropathy (DPN) is characterized by myelin abnormalities; however, the molecular mechanisms underlying such deficits remain obscure. To uncover the effects of diabetes on myelin alterations, we have analyzed myelin composition. In a streptozotocin-treated rat model of diabetic n...

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Bibliographic Details
Main Authors: Gaia Cermenati, Federico Abbiati, Solei Cermenati, Elisabetta Brioschi, Alessandro Volonterio, Guido Cavaletti, Enrique Saez, Emma De Fabiani, Maurizio Crestani, Luis M. Garcia-Segura, Roberto C. Melcangi, Donatella Caruso, Nico Mitro
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Journal of Lipid Research
Subjects:
diabetic neuropathy
liver X receptor
myelin composition
peripheral nerve
sterol-regulatory element binding factor-1c
fatty acid synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520407886

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http://www.sciencedirect.com/science/article/pii/S0022227520407886

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