Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure

Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure

Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene therapy to reconstitute HIV-specific CD4 T cells and...

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Bibliographic Details
Main Authors: Haishan Li, Tyler Lahusen, Lingzhi Xiao, Nidal Muvarak, Jana Blazkova, Tae-Wook Chun, C. David Pauza
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
HIV
AIDS
functional cure
immunotherapy
lentivirus vector
autologous
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030084X

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http://www.sciencedirect.com/science/article/pii/S232905012030084X

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