A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation

Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells. : Ozawa et al. present a murine tumor model re...

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Main Authors: Kristian W. Pajtler, Stefan M. Pfister
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718309896
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spelling doaj-5375370c6e9b4b5eac2631529d9a63262020-11-25T02:20:58ZengElsevierCell Reports2211-12472018-06-01231336993700A Mouse Ependymoma Model Provides Molecular Insights into Tumor FormationKristian W. Pajtler0Stefan M. Pfister1Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, GermanyHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany; Corresponding authorOzawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells. : Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells.http://www.sciencedirect.com/science/article/pii/S2211124718309896
collection DOAJ
language English
format Article
sources DOAJ
author Kristian W. Pajtler
Stefan M. Pfister
spellingShingle Kristian W. Pajtler
Stefan M. Pfister
A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
Cell Reports
author_facet Kristian W. Pajtler
Stefan M. Pfister
author_sort Kristian W. Pajtler
title A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
title_short A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
title_full A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
title_fullStr A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
title_full_unstemmed A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
title_sort mouse ependymoma model provides molecular insights into tumor formation
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2018-06-01
description Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells. : Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells.
url http://www.sciencedirect.com/science/article/pii/S2211124718309896
work_keys_str_mv AT kristianwpajtler amouseependymomamodelprovidesmolecularinsightsintotumorformation
AT stefanmpfister amouseependymomamodelprovidesmolecularinsightsintotumorformation
AT kristianwpajtler mouseependymomamodelprovidesmolecularinsightsintotumorformation
AT stefanmpfister mouseependymomamodelprovidesmolecularinsightsintotumorformation
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