Using Adjuvants to Drive T Cell Responses for Next-Generation Infectious Disease Vaccines

Using Adjuvants to Drive T Cell Responses for Next-Generation Infectious Disease Vaccines

Using adjuvants to drive features of T cell responses to vaccine antigens is an important technological challenge in the design of new and improved vaccines against infections. Properties such as T helper cell function, T cell memory, and CD8+ T cell cytotoxicity may play critical roles in optimal a...

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Bibliographic Details
Main Authors: Rekha R. Rapaka, Alan S. Cross, Monica A. McArthur
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Vaccines
Subjects:
T cell
adjuvant
differentiation
antigen presenting cell
CD8+ T cell
CD4+ T cell
Online Access:https://www.mdpi.com/2076-393X/9/8/820
Description
Summary:Using adjuvants to drive features of T cell responses to vaccine antigens is an important technological challenge in the design of new and improved vaccines against infections. Properties such as T helper cell function, T cell memory, and CD8+ T cell cytotoxicity may play critical roles in optimal and long-lived immunity through vaccination. Directly manipulating specific immune activation or antigen delivery pathways with adjuvants may selectively augment desired T cell responses in vaccination and may improve the effectiveness and durability of vaccine responses in humans. In this review we outline recently studied adjuvants in their potential for antigen presenting cell and T cell programming during vaccination, with an emphasis on what has been observed in studies in humans as available.
ISSN:2076-393X

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