Quenching protein dynamics interferes with HIV capsid maturation
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01856-y |
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doaj-53603f9efdef492b8a17f6357f9858ed2021-05-11T07:44:12ZengNature Publishing GroupNature Communications2041-17232017-11-018111210.1038/s41467-017-01856-yQuenching protein dynamics interferes with HIV capsid maturationMingzhang Wang0Caitlin M. Quinn1Juan R. Perilla2Huilan Zhang3Randall Shirra Jr.4Guangjin Hou5In-Ja Byeon6Christopher L. Suiter7Sherimay Ablan8Emiko Urano9Theodore J. Nitz10Christopher Aiken11Eric O. Freed12Peijun Zhang13Klaus Schulten14Angela M. Gronenborn15Tatyana Polenova16Department of Chemistry and Biochemistry, University of DelawareDepartment of Chemistry and Biochemistry, University of DelawareDepartment of Chemistry and Biochemistry, University of DelawareDepartment of Chemistry and Biochemistry, University of DelawarePittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of MedicineDepartment of Chemistry and Biochemistry, University of DelawarePittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of MedicineDepartment of Chemistry and Biochemistry, University of DelawareHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer InstituteHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer InstituteDFH PharmaPittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of MedicineHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer InstitutePittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of MedicineUniversity of Illinois, Theoretical and Computational Biophysics GroupPittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of MedicineDepartment of Chemistry and Biochemistry, University of DelawareThe process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.https://doi.org/10.1038/s41467-017-01856-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova |
| spellingShingle |
Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova Quenching protein dynamics interferes with HIV capsid maturation Nature Communications |
| author_facet |
Mingzhang Wang Caitlin M. Quinn Juan R. Perilla Huilan Zhang Randall Shirra Jr. Guangjin Hou In-Ja Byeon Christopher L. Suiter Sherimay Ablan Emiko Urano Theodore J. Nitz Christopher Aiken Eric O. Freed Peijun Zhang Klaus Schulten Angela M. Gronenborn Tatyana Polenova |
| author_sort |
Mingzhang Wang |
| title |
Quenching protein dynamics interferes with HIV capsid maturation |
| title_short |
Quenching protein dynamics interferes with HIV capsid maturation |
| title_full |
Quenching protein dynamics interferes with HIV capsid maturation |
| title_fullStr |
Quenching protein dynamics interferes with HIV capsid maturation |
| title_full_unstemmed |
Quenching protein dynamics interferes with HIV capsid maturation |
| title_sort |
quenching protein dynamics interferes with hiv capsid maturation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-11-01 |
| description |
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation. |
| url |
https://doi.org/10.1038/s41467-017-01856-y |
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