SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS

SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS

A study has been conducted to synthesize 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin using phenol derivate and investigate the capability of that compound, as an antioxidant. The synthesis was carried out through Mannich reaction using p-t-butylphenol, paraformaldehyde, and piperazine. Th...

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Main Author: Susy Yunita Prabawati
Format: Article
Language:English
Published: Jenderal Soedirman University 2016-11-01
Series:Molekul
Subjects:
antioxidant, Mannich reaction, p-t-butylphenol, 1,4-bis[(1-hydroxy-4-t-butyl-phenyl)methyl]piperazin.
Online Access:http://ojs.jmolekul.com/ojs/index.php/jm/article/view/244
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spelling doaj-53560a8013f840559d95af0d693872682020-11-25T01:58:32ZengJenderal Soedirman UniversityMolekul1907-97612503-03102016-11-0111222022910.20884/1.jm.2016.11.2.244203SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTSSusy Yunita Prabawati0Program Studi Kimia, Fakultas Sains dan Teknologi UIN Sunan Kalijaga YogyakartaA study has been conducted to synthesize 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin using phenol derivate and investigate the capability of that compound, as an antioxidant. The synthesis was carried out through Mannich reaction using p-t-butylphenol, paraformaldehyde, and piperazine. The product was characterized by IR and 1H NMR spectroscopic. Testing of antioxidant activity was done with the immersion of DPPH (1,1-diphenyl-2 picrylhydrazyl) free radical method. The product was obtained as a white solid, with a point of 252,7-254,7 ºC and a yield of 65.76%. The test of antioxidant activity with DPPH method showed that 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin had the IC50 values was 0.84 nM. It means that the 1,4- bis[(1-hydroxy-4-t-butyl-phenyl )methyl]piperazine has potential as antioxidants.http://ojs.jmolekul.com/ojs/index.php/jm/article/view/244antioxidant, Mannich reaction, p-t-butylphenol, 1,4-bis[(1-hydroxy-4-t-butyl-phenyl)methyl]piperazin.
collection DOAJ
language English
format Article
sources DOAJ
author Susy Yunita Prabawati
spellingShingle Susy Yunita Prabawati
SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
Molekul
antioxidant, Mannich reaction, p-t-butylphenol, 1,4-bis[(1-hydroxy-4-t-butyl-phenyl)methyl]piperazin.
author_facet Susy Yunita Prabawati
author_sort Susy Yunita Prabawati
title SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
title_short SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
title_full SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
title_fullStr SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
title_full_unstemmed SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS
title_sort synthesis of 1,4-bis [(1-hydroxy-4-t-butyl-phenyl) methyl]piperazine as antioxidants
publisher Jenderal Soedirman University
series Molekul
issn 1907-9761
2503-0310
publishDate 2016-11-01
description A study has been conducted to synthesize 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin using phenol derivate and investigate the capability of that compound, as an antioxidant. The synthesis was carried out through Mannich reaction using p-t-butylphenol, paraformaldehyde, and piperazine. The product was characterized by IR and 1H NMR spectroscopic. Testing of antioxidant activity was done with the immersion of DPPH (1,1-diphenyl-2 picrylhydrazyl) free radical method. The product was obtained as a white solid, with a point of 252,7-254,7 ºC and a yield of 65.76%. The test of antioxidant activity with DPPH method showed that 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin had the IC50 values was 0.84 nM. It means that the 1,4- bis[(1-hydroxy-4-t-butyl-phenyl )methyl]piperazine has potential as antioxidants.
topic antioxidant, Mannich reaction, p-t-butylphenol, 1,4-bis[(1-hydroxy-4-t-butyl-phenyl)methyl]piperazin.
url http://ojs.jmolekul.com/ojs/index.php/jm/article/view/244
work_keys_str_mv AT susyyunitaprabawati synthesisof14bis1hydroxy4tbutylphenylmethylpiperazineasantioxidants
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