Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy

Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy

Abstract Background To evaluate the transmembrane clearance (CLTM) of apixaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommendations. Methods Apixaban was added to the CRRT circuit and serial pre...

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Bibliographic Details
Main Authors: Lauren Andrews, Scott Benken, Xing Tan, Eric Wenzler
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Nephrology
Subjects:
Apixaban
Pharmacokinetics
Dialysis
Renal replacement therapy
Sieving coefficient
Saturation coefficient
Online Access:https://doi.org/10.1186/s12882-021-02248-7

Internet

https://doi.org/10.1186/s12882-021-02248-7

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