Changes in gastrointestinal structure and function caused by cirrhotic portal hypertension and related clinical manifestations

• Main Authors: SHANG Zhiyin, YANG Jingmao, CHEN Liping
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2017-02-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=8021

In clinical practice, up to 80% of patients with cirrhotic portal hypertension have varying degrees of gastrointestinal symptoms, which are associated with the changes in gastrointestinal structure, gastrointestinal dysfunction, and altered neurohumoral regulation. This article reviews the changes in gastrointestinal structure, gastrointestinal dysfunction, and altered neurohumoral regulation caused by cirrhotic portal hypertension, as well as the gastrointestinal clinical manifestations caused by such changes. It is pointed out that the research on the changes in gastrointestinal structure in cirrhotic patients with portal hypertension helps to effectively prevent and treat the complications of liver cirrhosis and improve gastrointestinal symptoms. In addition, the regulation of gastrointestinal function can improve patients′ symptoms and delay the progression of liver cirrhosis. Therefore, it is recommended to regularly evaluate the changes in gastrointestinal mucosa and vessels in patients with liver cirrhosis, in order to provide early treatment and reduce complications.