Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?

The majority of lung cancer cases result from complex interactions between smoking exposure, genetic susceptibility and a person's immune response to chronic inflammation or lung remodelling. Epidemiological studies confirm that susceptibility to developing chronic obstructive pulmonary disease...

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Main Authors:	R.J. Hopkins, R.P. Young
Format:	Article
Language:	English
Published:	Elsevier 2016-02-01
Series:	EBioMedicine
Subjects:	Lung cancer Chronic obstructive pulmonary disease Smoking exposure Ethnicity Genetic susceptibility
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396416300032

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spelling	doaj-534fb1d32df84ebe885b217e1628bd322020-11-25T01:18:12ZengElsevierEBioMedicine2352-39642016-02-014C131410.1016/j.ebiom.2016.01.005Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?R.J. HopkinsR.P. YoungThe majority of lung cancer cases result from complex interactions between smoking exposure, genetic susceptibility and a person's immune response to chronic inflammation or lung remodelling. Epidemiological studies confirm that susceptibility to developing chronic obstructive pulmonary disease (COPD), especially emphysema, is also closely linked to lung cancer susceptibility. Genetic epidemiology studies have consistently reported associations between the chromosome 15q25 locus with lung cancer and COPD. In addition, studies show this locus to be independently associated with cigarette consumption and nicotine addiction in a dose-response manner, primarily at lower levels of cigarette consumption. Studies that measure both cigarette consumption and lung function, together with extensive genotype analysis, will be needed to further unravel these complex relationships.http://www.sciencedirect.com/science/article/pii/S2352396416300032Lung cancerChronic obstructive pulmonary diseaseSmoking exposureEthnicityGenetic susceptibility
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	R.J. Hopkins R.P. Young
spellingShingle	R.J. Hopkins R.P. Young Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently? EBioMedicine Lung cancer Chronic obstructive pulmonary disease Smoking exposure Ethnicity Genetic susceptibility
author_facet	R.J. Hopkins R.P. Young
author_sort	R.J. Hopkins
title	Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?
title_short	Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?
title_full	Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?
title_fullStr	Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?
title_full_unstemmed	Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?
title_sort	gene by environment interaction linking the chromosome 15q25 locus with cigarette consumption and lung cancer susceptibility — are african american affected differently?
publisher	Elsevier
series	EBioMedicine
issn	2352-3964
publishDate	2016-02-01
description	The majority of lung cancer cases result from complex interactions between smoking exposure, genetic susceptibility and a person's immune response to chronic inflammation or lung remodelling. Epidemiological studies confirm that susceptibility to developing chronic obstructive pulmonary disease (COPD), especially emphysema, is also closely linked to lung cancer susceptibility. Genetic epidemiology studies have consistently reported associations between the chromosome 15q25 locus with lung cancer and COPD. In addition, studies show this locus to be independently associated with cigarette consumption and nicotine addiction in a dose-response manner, primarily at lower levels of cigarette consumption. Studies that measure both cigarette consumption and lung function, together with extensive genotype analysis, will be needed to further unravel these complex relationships.
topic	Lung cancer Chronic obstructive pulmonary disease Smoking exposure Ethnicity Genetic susceptibility
url	http://www.sciencedirect.com/science/article/pii/S2352396416300032
work_keys_str_mv	AT rjhopkins genebyenvironmentinteractionlinkingthechromosome15q25locuswithcigaretteconsumptionandlungcancersusceptibilityareafricanamericanaffecteddifferently AT rpyoung genebyenvironmentinteractionlinkingthechromosome15q25locuswithcigaretteconsumptionandlungcancersusceptibilityareafricanamericanaffecteddifferently
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Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility — Are African American Affected Differently?

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