Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in adulthood. In contrast, the small motoneurons that innervate the slow-contracting fibers (S-type motoneurons) are resistant and do not...

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Bibliographic Details
Main Authors: Félix Leroy, Boris Lamotte d'Incamps, Rebecca D Imhoff-Manuel, Daniel Zytnicki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
ALS
hyperexcitability
motoneuron
Online Access:https://elifesciences.org/articles/04046

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