Assessment of serum L-fucose in brain tumor cases

• Main Authors: Manjula S, Monteiro Flama, Aroor Annaya, Rao Suryanarayan, Annaswamy Raja, Rao Anjali
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Annals of Indian Academy of Neurology
• Subjects: Brain tumors; cysteine hydrochloride; glycosylation; L-Fucose
• Online Access: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=1;spage=33;epage=36;aulast=Manjula

<b>Background:</b> Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors. <b> Objective:</b> The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor. <b> Materials and Methods:</b> Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride. <b> Results:</b> There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values. <b> Conclusion:</b> Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.